The Role of Glucosamine in the Treatment of Breast Cancer: A Systematic Review

Abstract

Background: Breast cancer is a prevalent and multifactorial disease influenced by genetic, environmental, and lifestyle factors. Recent studies suggest that N-acetyl-D-glucosamine (D-GlcNAc) may have anti-tumor effects, particularly through its binding to HER2 receptors in breast cancer cells. Further research is needed to explore the potential of D-GlcNAc as a therapeutic agent in breast cancer treatment.

Methods: A comprehensive literature search from 2000 to July 2023 was conducted across multiple databases to examine the association between glucosamine intake and breast cancer risk. Studies were screened, and relevant data were extracted by two independent reviewers, with discrepancies resolved through consensus. Due to heterogeneity among studies, a qualitative and quantitative synthesis was performed.

Result: The literature review revealed mixed findings on the relationship between glucosamine intake and cancer risk, with some studies indicating a potential protective effect, particularly against breast cancer, through mechanisms like apoptosis, glycosylation, and inflammation modulation. However, inconsistencies in study designs and results precluded definitive conclusions. Further research is required to confirm glucosamine's role in breast cancer prevention and treatment.

conclusion: This review suggests that glucosamine may have protective effects against breast cancer through anti-inflammatory and cellular mechanisms. However, inconsistencies in study designs highlight the need for further large-scale research. Understanding glucosamine's role in cancer prevention could lead to new therapeutic approaches.